Study supports link between COVID-19 and 'COVID Toes'

Date:
July 2, 2020
Source:
Wiley
Summary:
A new study provides evidence supporting a link between 'COVID
toes' - - red sores or lesions on the feet and hands in children
and young adults -- and COVID-19.



FULL STORY ========================================================================== There's considerable controversy over whether "COVID toes" -- red sores
or lesions on the feet and hands in children and young adults -- are
truly caused by COVID-19. A new study published in the British Journal
of Dermatology provides evidence in support of the link.


==========================================================================
In most cases, affected individuals test negative with traditional
COVID-19 tests involving throat swabs and measurements of circulating antibodies, but this study's investigators found that the SARS-CoV-2
virus that causes COVID-19 was present in skin biopsies in children with symptoms of COVID toes, despite negative results from traditional tests.

Analyses detected the virus in skin's blood vessel endothelial cells,
as well as in the sweat glands. Electron microscopy in one biopsy also
found evidence of viral particles within endothelial cells.

"Our findings support a causal relation of SARS-CoV-2 with COVID toes.

Endothelial damage induced by the virus could be the key mechanism causing these lesions," said lead author Isabel Colmenero, MD, of Hospital
Infantil Universitario Nin~o Jesu's, in Spain. "Furthermore, vascular
damage could also explain some clinical features seen in patients with
severe COVID-19."

========================================================================== Story Source: Materials provided by Wiley. Note: Content may be edited
for style and length.


========================================================================== Journal Reference:
1. I. Colmenero, C. Santonja, M. Alonso‐Rian~o, L.

Noguera‐Morel, A. Herna'ndez‐Marti'n, D. Andina,
T. Wiesner, J.L. Rodri'guez‐Peralto, L. Requena, A. Torrelo.

SARS‐CoV‐2 endothelial infection causes COVID‐19
chilblains: histopathological, immunohistochemical and
ultraestructural study of 7 paediatric cases. British Journal of
Dermatology, 2020; DOI: 10.1111/bjd.19327 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2020/07/200702113716.htm

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